Everything Theresa and Mark say about Ted's Place is spot on. The location is great - walking distance to Lorelei, Islamorada Brewing, Mangrove Mikes, West Marine, and various other shops, bars, ice cream, restaurants, etc. The infinity pool is spectacular, and the large dock provided plenty of room for our 26' center console boat. Bedrooms are spacious and 4 of the 5 bedrooms are king beds with bathrooms.
Our party included 6 adults (ages 40+) and 4 teenagers (ages 13-16).
We are avid boaters, so the proximity of reefs, inshore and offshore fishing, and waterfront bars/restaurants was unmatched. Just be informed that boats bigger than about 30' will have a little bit of a challenge getting through the mangroves to the dock at the house, especially during low tide. The dock itself could easily accommodate multiple 20'+ boats.
Theresa was the best VRBO host we've ever had. She lives nearby and is very responsive, not that we really had any issues. But she did join us for dinner at Lorelei one night!
FYI for you boaters who tow your boat - I highly recommend paying the 60 bucks and launching at Safe Harbor Angler House. It's only a mile or so down the street and absolutely no wait to launch or retrieve as long as you avoid high-traffic times for the guides (8:00 - 9:00 am and 2:00 - 3:00 pm).