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21C Museum Hotel St Louis

Property class: 4.5

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Photo gallery for 21C Museum Hotel St Louis

A bar area with high wooden ceilings, a large mural, and a variety of seating options including tables and bar stools.
Massages
A modern lobby with a large glass sphere, seating areas, and a reception desk.
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
Bar (on property)

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(126 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(40 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(9 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed
  • Free Wi-Fi

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Deluxe Room, Accessible (Accessible)

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (Library)

A hotel room with a large bed, a wooden headboard, a nightstand with a lamp, a green armchair, and a large painting on the wall.

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout curtains

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed
  • Free Wi-Fi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed
  • Free Wi-Fi

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4.3 out of 5, Excellent, 4,260 reviews
The price is CHF 127
includes taxes & fees
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About this property

21C Museum Hotel St Louis

This smoke-free hotel features an indoor pool, a restaurant and a fitness centre. WiFi in public areas is free. Additionally, a bar/lounge, a steam room and a coffee shop/cafe are on-site. Change of towels is available on request
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and a safe. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries and hairdryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs and telephones. Additionally, rooms include complimentary bottles of water and an iron/ironing board. Change of towels and change of bedsheets can be requested. Housekeeping is provided on a daily basis.

Recreational amenities at the hotel include an indoor pool, a steam room and a fitness centre.
Guests can pamper themselves by indulging in the on-site spa services. Services include massages.
Our customers tell us they can't get enough of 21C Museum Hotel St Louis 's great location. During your stay, you're just a quick walk from St. Louis Union Station. Enjoy features like free WiFi in public areas, plus an indoor pool and a restaurant.
  • Free WiFi
  • Drinking and dining options include a coffee shop, a restaurant and a bar/lounge
  • Cooked-to-order breakfast served daily for a fee
  • Valet parking available for a fee
  • Take a swim in the indoor pool
  • Services include dry cleaning/laundry, a concierge and luggage storage
  • On-site recreation includes a gym and a steam room
  • Guests have great things to say about the helpful staff and the clean guestrooms
  • Within a 10-minute walk of St. Louis Union Station and City Museum
  • Dogs welcome for a fee
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness centre. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business centre and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

For a fee, guests can enjoy a cooked-to-order breakfast daily from 6:30 AM to 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 55 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
    • Service animals are exempt from fees.

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cots (infant beds) are not available.

Payment types at the property

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 55 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

This property is managed by a professional host. The provision of housing is linked to their trade, business or profession.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting
Front desk staff will greet guests on arrival at the property.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1457 out of 2066 reviews
Rating 8 - Good. 314 out of 2066 reviews
Rating 6 - Okay. 149 out of 2066 reviews
Rating 4 - Poor. 68 out of 2066 reviews
Rating 2 - Terrible. 78 out of 2066 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

Verified review

10/10 Excellent

Alexander

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Juan

Liked: Cleanliness, staff & service, property conditions & facilities
Great place to stay.
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
All the restaurants and bar were excellent.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Carl

Liked: Cleanliness
Great stay
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Kenneth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location, clean rooms, wonderful pool and hot tub
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

David

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location, staff, and bar/restaurant. The art gallery is an incredible bonus, along with the workout facilities!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Jenlyn

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I loved the art museum, the bar and cafe. The staff were so friendly and helpful
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms were clean and common areas well maintained. Breakfast was the best and the staff were all helpful and very kind to all guests. It was the best stay I've had in a hotel.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Really cool hotel with great onsite bar/restaurant, gym, pool and art gallery.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Sarah

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean and serviced daily. Hotel was lovely and well appointed.
Stayed 3 nights in Apr 2026
Verified review

10/10 Excellent

Rebecca

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful hotel
Stayed 3 nights in Mar 2026
Verified review

10/10 Excellent

sean

Location was wonderful, chris the bartender is fantastic
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel!
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Kathleen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Staff at front desk attentive and helpful Both places to eat onsite offer gluten free which was nice.
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

David

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This is my favorite hotel in the united states of America
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Alina

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun hotel
Stayed 3 nights in Apr 2026
Verified review

10/10 Excellent

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Absolutely beautiful, amazing breakfast, comfy bed!
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Chad

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A fantastic stay. Great breakfast and excellent pool area. Would stay again
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Jared

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
ABSOLUTELY PERFECT STAY! We loved the bar downstairs and the museum exhibit was perfect. We love the room, the game room, and the staff 10/10 recommend and will be staying again
Stayed 1 night in Dec 2025
Verified review

10/10 Excellent

Sheronda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun hotel.
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Brigitte

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
As a first time guest, I absolutely loved the entire experience. Being able to view the art on display, enjoy the arty decor throughout the hotel was a pleasure. We stayed in Deluxe King room.The room was nice and quiet, clean, welcoming and the shower stall is spacious.
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Heather

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean, staff was friendly and knowledgeable
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Donna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel with a friendly staff. The on-site restaurant is a great spot fir a cocktail after a day of exploring.
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful place, friendly staff! Enjoyed our stay and will definitely come back!!!
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Eric

Liked: Cleanliness, amenities, property conditions & facilities
Great place to stay. I recommend it and will stay again.
Stayed 1 night in Feb 2026