Find Cheap Flights from Madrid (MAD) to Santa Cruz (SRZ) from CHF 686

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Selected flight deals from Madrid to Santa Cruz

The lowest prices found within the past 7 days from Madrid to Santa Cruz were CHF 345 for one-way flights and CHF 686 for return flights, for the period specified. Prices and availability are subject to change. Additional terms apply.

Cheap Flights from Madrid to Santa Cruz & Flight Information
Origin airport IATA code
MAD
Destination airport IATA code
VVI
Number of flight options
1
Return price
CHF 685
Average flight time
5 hours 7 mins

Best Day to Book Flight from Madrid to Santa Cruz

Santa Cruz Flight Information

Traveling From
Madrid
Origin Airport IATA Code
MAD
Traveling To
Santa Cruz
Destination Airport IATA Code
SRZ
Number of Airlines Serving
Available Airlines
avianca, Boliviana De Aviacion, Air Europa, Iberia
Distance
Direct Flight Time
Flight Price
CHF 686

Need a car after flight from Madrid to Santa Cruz

Place to stay after flight from Madrid to Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
Dieses Hotel für Geschäftsreisende bietet dir einen angenehmen Aufenthalt in Santa Cruz. Freu dich auf WLAN-Internetzugang (kostenlos), Parken ohne Service (kostenlos) ...
9.4/10 Exceptional! (118 reviews)
"Good location and value for money."

Reviewed on 23 May 2026

Opens in a new windowIbis Santa Cruz DE LA Sierra
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
Dieses Hotel für Geschäftsreisende bietet dir einen angenehmen Aufenthalt in Santa Cruz. Freu dich auf inbegriffenes Frühstück, WLAN-Internetzugang (kostenlos) ...
8.2/10 Very Good! (378 reviews)
"Very well located three start hotel. Clean with everything you need for an in/out night. Hotel needs a redoing."

Reviewed on 27 May 2026

Opens in a new windowSun Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
Dieses Hotel im luxuriösen Stil bietet dir einen angenehmen Aufenthalt in Santa Cruz. Freu dich auf Parken ohne Service (kostenlos), Wellnessbereich und Dachterrasse. ...
9/10 Wonderful! (233 reviews)
"Amazing hotel"

Reviewed on 18 May 2026

Opens in a new windowMarriott Santa Cruz de la Sierra Hotel
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Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
Dieses Hotel mit Wellnessangebot bietet dir einen angenehmen Aufenthalt in Santa Cruz. Freu dich auf inbegriffenes Frühstück, WLAN-Internetzugang (kostenlos) ...
9/10 Wonderful! (380 reviews)
"The stuff they have excellent customer service"

Reviewed on 29 May 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Casa Por Temporadas

Casa Por Temporadas

2 out of 5
Barrio Las Pampitas, calle 3 Nro. 99 Santa Cruz Santa Cruz Department
Diese Pension bietet dir einen angenehmen Aufenthalt in Santa Cruz. Freu dich auf WLAN-Internetzugang (kostenlos), Balkone oder Patios und Satellitenempfang. ...
10/10 Exceptional! (1 review)
Great Service
"The front desk staff was amazing! We checked in during a rain storm and the hotel had been hit by lightning and their computers and they computers were out. The staff maintained their professionalism and got us in a room quickly. Thank you for your help"

Reviewed on 25 Jun 2025

Opens in a new windowCasa Por Temporadas
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
Dieses Hotel im luxuriösen Stil bietet dir einen angenehmen Aufenthalt in Santa Cruz. Freu dich auf inbegriffenes Frühstück, Wellnessbereich und 2 Bars/Lounges. ...
9/10 Wonderful! (428 reviews)
"Definitely I would’ve recommend anybody who is looking for hotel because the service was excellent make me feel special since I walked in into the place and also I was impressed how clean the place was…Thanks for the service guys…Keep up this way..thanks again for everything…I’ll see you soon.🙏"

Reviewed on 31 May 2026

Opens in a new windowCamino Real Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

^Savings based on all holiday package bookings with Flight + Hotel made on ebookers.ie from January 1, 2019 to December 31, 2019 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.